Tritium is a radioactive isotope of hydrogen, produced in heavy water, during CANDU reactor operations by neutron absorption. The tritium removal facility is used to extract tritium from the heavy water on a continuous basis and concentrates it in preparation for immobilization and storage. There are several internal and external hazards associated with the operation of a TRF, such as fires, onsite transportation accidents, exposure to radioactive materials, and the release of radioactive substances from the Tritium Immobilization System. This paper conducts a risk analysis for the TRF Cryogenic Refrigeration System (CRS), Air Cleanup System (ACS) and Tritium Immobilization System (TIS). This study includes Event Tree and Fault Tree and Analysis, system reliability, availability, and human reliability and risk estimation.